Ubx stock12/6/2023 ![]() UNITY’s neurology programs aim to explore novel mechanisms for cognitive benefit, and UNITY licensed its α-Klotho program, UBX2089, to Jocasta Neuroscience for development and commercialization in cognitive dysfunction associated with neurological and psychiatric conditions.Īccording to the National Eye Institute, diabetic retinopathy is the most prominent complication of diabetes and the leading cause of blindness in working age individuals. A separate program directed at Tie2 activation is being explored in preclinical studies for multiple indications, including Diabetic Kidney Disease. UNITY’s Tie2/VEGF bispecific molecule is designed to target two pathways believed to be core to disease progression in DME and AMD. Tie2 pathway activity decreases with age and leads to the loss of vascular barrier integrity and diseased blood vessel formation in the eye. UNITY is also advancing programs that target the Tie2 signaling pathway for therapeutic benefit. UBX1967 remains in the portfolio as a molecularly distinct backup to UBX1325. In addition, in a Phase 2 study (ENVISION) of UBX1325 in patients with wet AMD, two injections of UBX1325 led to maintenance of visual acuity through 24 weeks after withdrawal of anti-VEGF. UBX1325 demonstrated a statistically significant and clinically meaningful improvement in mean Best Corrected Visual Acuity (BCVA) through 48 weeks compared to sham treatment in the Phase 2 BEHOLD study in patients with DME. ![]() ![]() The small molecule targets Bcl-xL, a protein that senescent cells rely on for survival. No cash balance or cash flow is included in the calculation.UNITY’s most advanced drug candidate, UBX1325, is currently being evaluated for the treatment of age-related diseases of the eye – including diabetic macular edema, diabetic retinopathy, and age-related macular degeneration. Please note all regulatory considerations regarding the presentation of fees must be taken into account. Backtested results are adjusted to reflect the reinvestment of dividends and other income and, except where otherwise indicated, are presented gross-of fees and do not include the effect of backtested transaction costs, management fees, performance fees or expenses, if applicable. Actual performance may differ significantly from backtested performance. Further, backtesting allows the security selection methodology to be adjusted until past returns are maximized. Since trades have not actually been executed, results may have under- or over-compensated for the impact, if any, of certain market factors, such as lack of liquidity, and may not reflect the impact that certain economic or market factors may have had on the decision-making process. Specifically, backtested results do not reflect actual trading or the effect of material economic and market factors on the decision-making process. Backtested performance is developed with the benefit of hindsight and has inherent limitations. ![]() This information is provided for illustrative purposes only. No representations and warranties are made as to the reasonableness of the assumptions. Certain assumptions have been made for modeling purposes and are unlikely to be realized. Changes in these assumptions may have a material impact on the backtested returns presented. General assumptions include: XYZ firm would have been able to purchase the securities recommended by the model and the markets were sufficiently liquid to permit all trading. Backtested results are calculated by the retroactive application of a model constructed on the basis of historical data and based on assumptions integral to the model which may or may not be testable and are subject to losses. The results reflect performance of a strategy not historically offered to investors and does not represent returns that any investor actually attained. Backtested performance is not an indicator of future actual results. Disclaimer: The TipRanks Smart Score performance is based on backtested results.
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